https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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Nanotechnology offers a range of possibilities to contribute to biology. Listed here I will current examples the place nanofabrication – the opportunity to make confined buildings with Proportions at will – is made use of to look at the biophysics of one molecules and cells. I'll current some illustrations from our lab:
Our team scientific tests bacterial cell division and is particularly aiming to represent a ‘bottom up biology’ in synthetic cells which will autonomously divide. Our key curiosity lies in cell division, chromatin composition, and spatial Management.
[Laughs] ‘It was certainly an excellent danger! At the time, I had been perfectly informed that it could go Erroneous Which I could develop into a lot less productive, but I just dismissed that. Curiosity has usually been my strongest driving force. And fortunately all of it worked out.’
Our do the job was quickly adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 revealed their results on transistors constructed from one- and multi-walled carbon nanotubes in Utilized Physics Letters.
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Immediate immobilization of native yeast iso-one cytochrome c on bare gold: quick electron relay to redox enzymes and zeptomole protein-movie voltammetry
What distinguishes biology from chemistry is always that these components collectively make up a living technique. The secret of explained life, I feel, lies in the interactions, the interplay of Those people molecules. The large dilemma in regards to the origin of life remains unanswered. How did we ever evolve from basic molecules into your incredibly elaborate techniques we see now? We have no idea. I want to work on These types of significant, open inquiries.’
Nanopores characterize a sublime and functional Resource to evaluate solitary molecules. We investigation novel detection modes with reliable-condition nanopores along with different solutions to evaluate proteins with nanopores. Assignments encompass the following:
2003, demonstrated the main biosensors built away from a carbon nanotube; settled the construction and mechanism of DNA maintenance proteins; and discovery of a different strategy for fabricating sound-state nanopores for DNA translocation
1). The present–voltage curves showed important modulations with gate voltage, even at room temperature, which was cees dekker in keeping with band bending inside a ~0.six eV bandgap semiconducting nanotube. These data also showed which the conductance might be modulated by 6 orders of magnitude by changing the gate voltage. The outcome of the perform — a place-temperature transistor produced from one carbon nanotube molecule — were revealed in Mother nature in Might 1998.
An built-in microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
‘That concerns the synthetic mobile, as part of the Dutch BaSyC initiative. Craig Venter seemed major-down in These times and discovered about five hundred genes which might be minimally required for the functioning cell. We want to glance bottom-up: how do we transfer from the few molecules to a complete biological process?
Visualization of unstained DNA nanostructures with Highly developed in-focus transmission electron microscopy strategies
The biophysicist from Delft – who has long been One of the more cited experts while in the Netherlands For a long time – requires his responsibility to add to your clarification and popularisation of his function at the border of physics and biology exceptionally severely and often appears during the media; if not to discuss his function, then about the connection amongst science and his Christian faith.