New Step by Step Map For cees dekker
New Step by Step Map For cees dekker
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis interests involve:
Human Rad51 filaments on double- and one-stranded DNA: correlating regular and irregular kinds with recombination functionality.
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Deposition and atomic force microscopy of individual phthalocyanine polymers concerning nanofabricated electrodes
2010, made a brand new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by way of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into stable-point out nanopores
Our study ranges in the biophysics of DNA to synthetic cells and beyond. Please take a look down below within the spectrum of our present-day jobs.
‘In the beginning we checked out Organic methods by using a Actual physical see and acted on The idea with the tools we knew. It took a couple of years in advance of we started Doing work extra on the massive biological concerns. I then started to simply call it nanobiology, a time period that didn't exist at the time.
2011, initial in vitro measurements of transport across a single biomimetic nuclear pore elaborate; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
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1). The current–voltage curves showed significant modulations with gate voltage, even at area temperature, which was consistent with band bending in the ~0.6 eV bandgap semiconducting nanotube. These knowledge also confirmed that the conductance may very well be modulated by six orders of magnitude by shifting the gate voltage. The results of this do the job — a space-temperature transistor constructed from just one carbon nanotube molecule — ended up published in Character in May well 1998.
An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes
1999, initially measurement of your wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for your new Luttinger description of interacting electrons in nanotubes
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Solid-state nanopores have proven to become a remarkably flexible probe for single-molecule analysis of DNA. I will explain many https://www.ceesdekker.net of our the latest conclusions – specially DNA knots – together with our initiatives to develop the abilities of sound-condition nanopores even even more, while in the route of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.